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Research Projects

Microbial Modulation of the Tumour Microenvironment in Pancreatic Cancer: Early Diagnostic Markers and Candidate Therapeutic Targets

Professor Jonathan Blackburn Institute of Infectious Disease & Molecular Medicine, Faculty of Health Sciences, University of Cape Town Email Title of the project Microbial modulation of the tumour microenvironment in pancreatic cancer: early diagnostic markers and candidate therapeutic targets Project Description The project employs a multi-omic approach to biomarker identification, validation and elucidation of molecular […]

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Published: 25 March 2024
Updated: 8 April 2024
Categories: CANSA Research, Research Projects

Current Type B and C Grant Holders

Our Type B and Type C Research projects support research conducted by post-graduate students with supervision from the host institution. We currently fund and support four Type B and Type C Research projects at universities across South Africa. Dr Sarah Day Senior Research Officer, Cancer Research Initiative, Faculty of Health Sciences, University of Cape Town […]

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Published: 15 March 2024
Updated: 20 March 2024
Categories: CANSA Research, Research Projects

Dr Eloise van der Merwe – Knockdown of LRP/LR Impedes Multiple Cancer Hallmarks in Lung Cancer Cells

Dr Eloise van der Merwe of the School of Molecular and Cell Biology, University of the Witwatersrand delivered a poster at the ASCB/EMBO Cell Bio 2023 conference in Boston, USA from 2-6 December 2023 as part of the late Prof Stefan Weiss’s CANSA-funded project. Read more… Download the poster Abstract:  Knockdown of LRP/LR Impedes Multiple […]

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Published: 6 February 2024
Updated: 7 February 2024
Categories: CANSA Research, Notice Board, Research Findings, Research Projects

CANSA Head of Research serves as a Member on the AWACAN-ED Steering Group

AWACAN-ED (African aWAreness of CANcer & Early Diagnosis) is an NIHR-funded Global Health Research Group focussing on Advancing Early Diagnosis of Cancer in Southern Africa. CANSA Head of Research, Prof Jane Harries, is a member of the AWACAN-ED Steering Group. The study aims to advance the early diagnosis of cancer in Southern Africa by developing and evaluating electronic […]

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Published: 8 August 2022
Updated: 8 August 2022
Categories: CANSA Research, Notice Board, Research Findings, Research Projects

MSD Global Oncology Policy Grant

See our latest (24 January 2024) publication in ecancermedical science titled: Harnessing the law to advance equitable cancer care in South Africa: exploring the feasibility, desirability and added value of a dedicated national cancer act.

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Published: 7 August 2022
Updated: 29 February 2024
Categories: CANSA Highlights, CANSA Research, Notice Board, Research Findings, Research Projects

Genetic Risk Factors for Breast Cancer in South Africa

Prof Christopher Mathew Department of Human Genetics and Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand Email   A/Prof Michael Urban Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, University of Stellenbosch Email     Title of the project Genetic risk factors for breast cancer in South Africa: A discovery, […]

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Published: 8 April 2022
Updated: 9 May 2022
Categories: CANSA Research, Research Projects

Improving Cure for Lymphoma Patients in South Africa by Enhancing Access to Early and Accurate Lymphoma Diagnosis

A/Prof Estelle Verburgh Clinical Haematology, Department of Medicine, University of Cape Town Email Title of the project Improving cure for lymphoma patients in South Africa by enhancing access to early and accurate lymphoma diagnosis Project Description Non-Hodgkin lymphoma is the seventh most common cancer in South Africa, sixth when Hodgkin and non-Hodgkin lymphoma are combined. […]

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Published: 8 April 2022
Updated: 3 August 2023
Categories: CANSA Research, Research Projects

Vitamin D: Determinants of serum 25-hydroxyvitamin D levels in adults in the Western Cape Province of South Africa

Vitamin D deficiency has been associated with an increased risk of breast, prostate and colorectal cancer. Exposure to solar radiation is a major source of Vitamin D production. Greater exposure is required by those with darker skin tones in order to produce Vitamin D. We funded a study led by Janicke Visser at the Division of […]

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Published: 6 September 2019
Updated: 9 March 2021
Categories: CANSA Research, Research Findings, Research Projects

Type A projects which ended on 31 March 2019

The following Type A projects came to an end on 31 March 2019: Dr Jennifer Geel – Charlotte Maxeke Johannesburg Academic Hospital / WITS / South African Children’s Cancer Study Group. Hodgkin Lymphoma in South African Children Adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group Dr Catherine Kaschula – Stellenbosch University. Identification of […]

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Published: 4 June 2019
Updated: 11 March 2021
Categories: Research Findings, Research Projects

Physical Properties of Core and HBeAg/Precursors and Host-Pathogen Interactions Leading to Development of Hepatocellular Carcinoma

Prof Anna Kramvis Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand Email Title of the project Physical properties of core and HBeAg/precursors and host-pathogen interactions leading to development of hepatocellular carcinoma. Project Description Hepatitis B virus (HBV) infection is a major cause of acute and chronic hepatitis, liver cirrhosis and hepatocellular […]

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Published: 15 April 2019
Categories: Research Projects

Molecular Mechanisms of Breast Cancer Risk Reduction by SM6Met, a Well Characterized Cyclopia Extract

Prof Ann Louw Department of Biochemistry, Stellenbosch University al@sun.ac.za Title of the project Molecular mechanisms of breast cancer risk reduction by SM6Met, a well characterized Cyclopia extract. Project Description Globally and in South Africa breast cancer is the most frequent malignancy in women. Most breast cancers are oestrogen receptor (ER) positive and require oestrogen for […]

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Published: 4 April 2019
Updated: 4 April 2019
Categories: Research Projects

Identification of Novel Cancer Biomarkers with Diagnostic and Therapeutic Potential for Cervical and Oesophageal Cancers Using a Targeted Proteomic Approach

Prof Virna Leaner Division of Medical Biochemistry & Structural Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town Email Title of the project Identification of novel cancer biomarkers with diagnostic and therapeutic potential for cervical and oesophageal cancers using a targeted proteomic approach. Project Description Cancer continues to be a […]

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Published: 4 April 2019
Updated: 30 March 2021
Categories: Research Projects

Immunity, Knowledge, Behaviour and HPV Infection Rates after Pre-Adolescent HPV Vaccination during the VACCS 1 and 2 Trials (ImmunoVACCS)

Dr Haynes van der Merwe Department of Obstetrics and Gynaecology, Gynaecologic Oncology Unit, Tygerberg Hospital and Stellenbosch University Email Title of the project Immunity, knowledge, behaviour and HPV infection rates after pre-adolescent HPV vaccination during the VACCS 1 and 2 trials (ImmunoVACCS). Project Description The project focuses on the reduction of risk for cervical cancer, […]

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Published: 4 April 2019
Updated: 11 February 2021
Categories: Research Projects

HDL and Anthracycline-Induced Cardiotoxicity

Prof Sandrine Lecour Hatter Institute, Faculty of Health Sciences, University of Cape Town Email Title of the project HDL and anthracycline-induced cardiotoxicity. Project Description Anthracycline-based chemotherapy has been widely accepted to have an increased rise for dose-dependent cardiotoxicity, particularly in patients with pre-existing conditions such as hypertension, obesity, diabetes and cardiac disease. Unfortunately, approximately 21% […]

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Published: 4 April 2019
Categories: Research Projects

The In Vitro Possible Photodiagnosis and Photodynamic Therapy Treatment of Colon Cancer

Project ended 30 June 2021 Dr Cherie Kruger Laser Research Centre, Faculty of Health Sciences, University of Johannesburg Email Title of the project “The In Vitro Possible Photodiagnosis and Photodynamic Therapy Treatment of Colon Cancer”. Project Description Colorectal cancer (CRC) is the fourth most common cancer in South Africa (SA), and the sixth most lethal. […]

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Published: 4 April 2019
Updated: 8 April 2022
Categories: Research Projects

Immunogenic Fingerprinting in the New Era for Personalized Medicine: Serum Amyloid A and Macrophages in the Tumour-Microenvironment

Prof Anna-Mart Engelbrecht Department of Physiological Sciences, Stellenbosch University ame@sun.ac.za Title of the project Immunogenic fingerprinting in the new era for personalized medicine: Serum amyloid A and macrophages in the tumour-microenvironment Project Description The mediators and cellular effectors of inflammation are important role players of the tumour micro-environment. In some cancer types, inflammatory conditions are […]

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Published: 4 April 2019
Updated: 11 February 2021
Categories: Research Projects

Discovery of Novel Targets in Pancreatic Cancer by Investigating Aberrant Signalling Pathways

Project ended 30 June 2022 Prof Geoffrey Candy Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand Email Title of the project Discovery of novel targets in pancreatic cancer by investigating aberrant signalling pathways. Project Description Pancreatic cancer (PDAC) is a devastating and aggressive cancer with a poor prognosis despite several treatment strategies. […]

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Published: 4 April 2019
Updated: 29 November 2022
Categories: Research Projects

Type A projects which ended on 31 March 2018

The following Type A projects came to an end on 31 March 2018: Prof Ans Baeyens – University of the Witwatersrand. Genetic screening of triple negative and young breast cancer patients in South Africa Prof Sinead Delany-Moretlwe – University of the Witwatersrand. Factors associated with anogenital HPV infection and disease prevalence, incidence, persistence: a prospective cohort […]

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Published: 23 October 2018
Categories: Research Findings, Research Projects

Investigating the Functional Consequences of Novel EPHA2 Polymorphisms on KSHV Infectivity and KS Development Among South African HIV/AIDS Patients

Dr Georgia Schäfer Division of Medical Biochemistry, University of Cape Town Email Title of the project Investigating the functional consequences of novel EPHA2 polymorphisms on KSHV infectivity and KS development among South African HIV/AIDS patients. Project Description Kaposi’s Sarcoma (KS) is the most common Acquired Immune Deficiency Syndrome (AIDS)-related malignancy globally and is of particular significance in […]

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Published: 17 September 2018
Updated: 19 September 2018
Categories: Research Projects

Overcoming Glioma Resistance Through Lethal Autophagic Flux Control – A Multidisciplinary Approach

Project ended 30 June 2021 Prof Ben Loos Department of Physiological Sciences, Stellenbosch University Email Project Title Overcoming glioma resistance through lethal autophagic flux control – a multidisciplinary approach. Project Description The 2016 Nobel prize for medicine/physiology was awarded for the discovery of the cellular protein degradation and quality control process termed autophagy. Although we […]

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Published: 17 September 2018
Updated: 8 April 2022
Categories: Research Projects

Verification of the Therapeutic Potential of LRP/LR Downregulation and anti-LRP/LR Antibody IgG1-iS18 for the Prevention of Tumour Formation and Metastasis in BALB/c Nude Mice

The project ended on 30 June 2021 The late Prof Stefan Weiss School of Molecular and Cell Biology, University of the Witwatersrand Email Title of the project Verification of the therapeutic potential of LRP/LR downregulation and anti-LRP/LR antibody IgG1-iS18 for the prevention of tumour formation and metastasis in BALB/c nude mice. Project Description Cancer plays a […]

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Published: 13 September 2018
Updated: 7 February 2024
Categories: Research Projects

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