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Research Projects

MSD Global Oncology Policy Grant

Study Title Legal frameworks and policies: advancing innovative approaches to cancer care in South Africa. Study Description This is a  collaborative study with CANSA, Cancer Alliance,  University of the Witwatersrand and the Institute for Cancer Policy, Comprehensive Cancer Centre at Kings College, London. The study explores whether a dedicated National Cancer Act in South Africa […]

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Published: 8 Aug 2022
Updated: 8 Aug 2022
Categories: CANSA Research, Notice Board, Research Findings, Research Projects

CANSA Head of Research serves as a Member on the AWACAN-ED Steering Group

AWACAN-ED (African aWAreness of CANcer & Early Diagnosis) is an NIHR-funded Global Health Research Group focussing on Advancing Early Diagnosis of Cancer in Southern Africa. CANSA Head of Research, Prof Jane Harries, is a member of the AWACAN-ED Steering Group. The study aims to advance the early diagnosis of cancer in Southern Africa by developing and evaluating electronic […]

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Published: 8 Aug 2022
Updated: 8 Aug 2022
Categories: CANSA Research, Notice Board, Research Findings, Research Projects

CANSA Funded Research Projects for Master of Public Health Students

We are seeking to fund two Master of Public Health students to conduct research on two topics that will form part of their Master’s dissertation. These are both qualitative research projects. The closing date for submission is 31 July 2022.

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Published: 10 Jul 2022
Updated: 5 Aug 2022
Categories: CANSA Research, Notice Board, Research Projects

Genetic Risk Factors for Breast Cancer in South Africa

Prof Christopher Mathew Department of Human Genetics and Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand Email   A/Prof Michael Urban Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, University of Stellenbosch Email     Title of the project Genetic risk factors for breast cancer in South Africa: A discovery, […]

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Published: 8 Apr 2022
Updated: 9 May 2022
Categories: CANSA Research, Research Projects

Improving Cure for Lymphoma Patients in South Africa by Enhancing Access to Early and Accurate Lymphoma Diagnosis

A/Prof Estelle Verburgh Clinical Haematology, Department of Medicine, University of Cape Town Email Title of the project Improving cure for lymphoma patients in South Africa by enhancing access to early and accurate lymphoma diagnosis Project Description Non-Hodgkin lymphoma is the seventh most common cancer in South Africa, sixth when Hodgkin and non-Hodgkin lymphoma are combined. […]

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Published: 8 Apr 2022
Updated: 25 Apr 2022
Categories: CANSA Research, Research Projects

Vitamin D: Determinants of serum 25-hydroxyvitamin D levels in adults in the Western Cape Province of South Africa

Vitamin D deficiency has been associated with an increased risk of breast, prostate and colorectal cancer. Exposure to solar radiation is a major source of Vitamin D production. Greater exposure is required by those with darker skin tones in order to produce Vitamin D. We funded a study led by Janicke Visser at the Division of […]

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Published: 6 Sep 2019
Updated: 9 Mar 2021
Categories: CANSA Research, Research Findings, Research Projects

Type A projects which ended on 31 March 2019

The following Type A projects came to an end on 31 March 2019: Dr Jennifer Geel – Charlotte Maxeke Johannesburg Academic Hospital / WITS / South African Children’s Cancer Study Group. Hodgkin Lymphoma in South African Children Adolescents from 2000-2010: A first report by the South African Children’s Cancer Study Group Dr Catherine Kaschula – Stellenbosch University. Identification of […]

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Published: 4 Jun 2019
Updated: 11 Mar 2021
Categories: Research Findings, Research Projects

Physical Properties of Core and HBeAg/Precursors and Host-Pathogen Interactions Leading to Development of Hepatocellular Carcinoma

Prof Anna Kramvis Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand Email Title of the project Physical properties of core and HBeAg/precursors and host-pathogen interactions leading to development of hepatocellular carcinoma. Project Description Hepatitis B virus (HBV) infection is a major cause of acute and chronic hepatitis, liver cirrhosis and hepatocellular […]

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Published: 15 Apr 2019
Categories: Research Projects

Molecular Mechanisms of Breast Cancer Risk Reduction by SM6Met, a Well Characterized Cyclopia Extract

Prof Ann Louw Department of Biochemistry, Stellenbosch University al@sun.ac.za Title of the project Molecular mechanisms of breast cancer risk reduction by SM6Met, a well characterized Cyclopia extract. Project Description Globally and in South Africa breast cancer is the most frequent malignancy in women. Most breast cancers are oestrogen receptor (ER) positive and require oestrogen for […]

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Published: 4 Apr 2019
Updated: 4 Apr 2019
Categories: Research Projects

Identification of Novel Cancer Biomarkers with Diagnostic and Therapeutic Potential for Cervical and Oesophageal Cancers Using a Targeted Proteomic Approach

Prof Virna Leaner Division of Medical Biochemistry & Structural Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town Email Title of the project Identification of novel cancer biomarkers with diagnostic and therapeutic potential for cervical and oesophageal cancers using a targeted proteomic approach. Project Description Cancer continues to be a […]

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Published: 4 Apr 2019
Updated: 30 Mar 2021
Categories: Research Projects

Immunity, Knowledge, Behaviour and HPV Infection Rates after Pre-Adolescent HPV Vaccination during the VACCS 1 and 2 Trials (ImmunoVACCS)

Dr Haynes van der Merwe Department of Obstetrics and Gynaecology, Gynaecologic Oncology Unit, Tygerberg Hospital and Stellenbosch University Email Title of the project Immunity, knowledge, behaviour and HPV infection rates after pre-adolescent HPV vaccination during the VACCS 1 and 2 trials (ImmunoVACCS). Project Description The project focuses on the reduction of risk for cervical cancer, […]

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Published: 4 Apr 2019
Updated: 11 Feb 2021
Categories: Research Projects

HDL and Anthracycline-Induced Cardiotoxicity

Prof Sandrine Lecour Hatter Institute, Faculty of Health Sciences, University of Cape Town Email Title of the project HDL and anthracycline-induced cardiotoxicity. Project Description Anthracycline-based chemotherapy has been widely accepted to have an increased rise for dose-dependent cardiotoxicity, particularly in patients with pre-existing conditions such as hypertension, obesity, diabetes and cardiac disease. Unfortunately, approximately 21% […]

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Published: 4 Apr 2019
Categories: Research Projects

The In Vitro Possible Photodiagnosis and Photodynamic Therapy Treatment of Colon Cancer

Project ended 30 June 2021 Dr Cherie Kruger Laser Research Centre, Faculty of Health Sciences, University of Johannesburg Email Title of the project “The In Vitro Possible Photodiagnosis and Photodynamic Therapy Treatment of Colon Cancer”. Project Description Colorectal cancer (CRC) is the fourth most common cancer in South Africa (SA), and the sixth most lethal. […]

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Published: 4 Apr 2019
Updated: 8 Apr 2022
Categories: Research Projects

Immunogenic Fingerprinting in the New Era for Personalized Medicine: Serum Amyloid A and Macrophages in the Tumour-Microenvironment

Prof Anna-Mart Engelbrecht Department of Physiological Sciences, Stellenbosch University ame@sun.ac.za Title of the project Immunogenic fingerprinting in the new era for personalized medicine: Serum amyloid A and macrophages in the tumour-microenvironment Project Description The mediators and cellular effectors of inflammation are important role players of the tumour micro-environment. In some cancer types, inflammatory conditions are […]

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Published: 4 Apr 2019
Updated: 11 Feb 2021
Categories: Research Projects

Discovery of Novel Targets in Pancreatic Cancer by Investigating Aberrant Signalling Pathways

Project ended 30 June 2022 Prof Geoffrey Candy Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand Email Title of the project Discovery of novel targets in pancreatic cancer by investigating aberrant signalling pathways. Project Description Pancreatic cancer (PDAC) is a devastating and aggressive cancer with a poor prognosis despite several treatment strategies. […]

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Published: 4 Apr 2019
Updated: 29 Nov 2022
Categories: Research Projects

Type A projects which ended on 31 March 2018

The following Type A projects came to an end on 31 March 2018: Prof Ans Baeyens – University of the Witwatersrand. Genetic screening of triple negative and young breast cancer patients in South Africa Prof Sinead Delany-Moretlwe – University of the Witwatersrand. Factors associated with anogenital HPV infection and disease prevalence, incidence, persistence: a prospective cohort […]

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Published: 23 Oct 2018
Categories: Research Findings, Research Projects

Investigating the Functional Consequences of Novel EPHA2 Polymorphisms on KSHV Infectivity and KS Development Among South African HIV/AIDS Patients

Dr Georgia Schäfer Division of Medical Biochemistry, University of Cape Town Email Title of the project Investigating the functional consequences of novel EPHA2 polymorphisms on KSHV infectivity and KS development among South African HIV/AIDS patients. Project Description Kaposi’s Sarcoma (KS) is the most common Acquired Immune Deficiency Syndrome (AIDS)-related malignancy globally and is of particular significance in […]

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Published: 17 Sep 2018
Updated: 19 Sep 2018
Categories: Research Projects

Overcoming Glioma Resistance Through Lethal Autophagic Flux Control – A Multidisciplinary Approach

Project ended 30 June 2021 Prof Ben Loos Department of Physiological Sciences, Stellenbosch University Email Project Title Overcoming glioma resistance through lethal autophagic flux control – a multidisciplinary approach. Project Description The 2016 Nobel prize for medicine/physiology was awarded for the discovery of the cellular protein degradation and quality control process termed autophagy. Although we […]

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Published: 17 Sep 2018
Updated: 8 Apr 2022
Categories: Research Projects

Verification of the Therapeutic Potential of LRP/LR Downregulation and anti-LRP/LR Antibody IgG1-iS18 for the Prevention of Tumour Formation and Metastasis in BALB/c Nude Mice

Project ended 30 June 2021 Prof Stefan Weiss School of Molecular and Cell Biology, University of the Witwatersrand Email Title of the project Verification of the therapeutic potential of LRP/LR downregulation and anti-LRP/LR antibody IgG1-iS18 for the prevention of tumour formation and metastasis in BALB/c nude mice. Project Description Cancer plays a major role in South […]

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Published: 13 Sep 2018
Updated: 8 Apr 2022
Categories: Research Projects

The Impact of HIV Status on Staging, Treatment and Outcomes in Locally Advanced Cervical Carcinoma

Project ended 31 March 2019 A/Prof Hannah Simonds Medical Imaging and Clinical Oncology/Radiation Oncology, Stellenbosch University/Tygerberg Hospital Email Title of the project The impact of HIV status on staging, treatment and outcomes in locally advanced cervical carcinoma. Project Description The ideal staging techniques and treatment regimens for HIV-infected cervical carcinoma patients have yet to be […]

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Published: 13 Sep 2018
Updated: 3 Oct 2019
Categories: Research Projects

Impact of Cisplatin-induced Hearing Loss on Health-related Quality of Life: A Prospective Cohort Study

A/Prof Lebogang Ramma Department of Health & Rehabilitation Sciences, University of Cape Town Email Title of the project Impact of cisplatin-induced hearing loss on health-related quality of life: A prospective cohort study. Project Description Cisplatin is a highly effective and widely used chemotherapeutic drug for the treatment of solid tumours. It is also associated with […]

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Published: 13 Sep 2018
Updated: 11 Feb 2021
Categories: Research Projects

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