New Vaccines Reducing Risk of Cervical Cancer

General:

• Approved by FDA  June 2006
• Approved by SA MCC Feb 2008
• Manufacturer: Merck (Pty) Ltd; (MSD : Merck, Sharpe & Dohme)
• Only a doctor or healthcare professional can decide if Gardisal is right for you or your daughter

Actions (package insert details)

• Helps protect against multiple strains
• Quadrivalent : strains 6,11,16 & 18
• Is given as 3 injections over 6 months
• Is for girls and young women ages 9 to 26.
• Is not for women who are pregnant.
• Does not treat cervical cancer or genital warts.
• Will not protect against diseases caused by other HPV types
• It’s important to continue routine cervical cancer screenings
• Not for anyone who is allergic to ingredients of Gardisal  ( should not receive injection)

Costs single exit price :

• R700.00 per injection

Each 0,5 ml dose contains:

• Human papilloma virus:
• Type 6 l 1 protein 20,0 μg
• Type 11 l 1 protein 40,0 μg
• Type 16 l 1 protein 40,0 μg
• Type 18 l 1 protein 20,0 μg

Side effects:

• Pain
• Swelling
• Itching
• Redness at injection site
• Fever
• Nausea
• Dizziness
• Vomiting
• Fainting

Cervarix

 General:

• Approved by FDA  March 2007
• Approved by SA MCC Feb 2008
• Manufacturer: Glaxosmithkline, South Africa (Pty) Ltd

Actions (package insert details)

• Helps Protect Against Two  Strains

• Bivalent : Strains 16 And 18
• The immune system will make antibodies against HPV types 16 and 18.
• Has been shown to prevent HPV types 16 and 18 related diseases in women 15-25 Years of age
• Cervarix® also stimulates production of antibodies in females 10-14 years of age.
• Is not used to treat HPV related diseases already present at the time of vaccination.
• In clinical trials, oral contraceptives (e.g. the pill) did not reduce the protection obtained by Cervarix®. not  given if person is allergic (hypersensitive) to any of the active substances or any of the other ingredients of Cervarix

Costs:

• Single Exit Price : R720.00

Each 0,5 ml dose contains:

• human papilloma virus:
• type 16 l 1 protein 20,0 μg
• type 18 l 1 protein 20,0 μg

• Given as an injection into the muscle of the upper arm.
  • First injection: at chosen date
  • Second injection: 1 month after first injection
  • Third injection: 6 months after first injection

Special care with Cervarix® if

• has a bleeding problem or bruises easily.

• has any disease which reduces her resistance to infection such as HIV infection
• The duration of protection after vaccination is currently unknown.
• Cervarix® may not have an optimal effect if used with medicines that suppress the immune system.
• There are insufficient data concerning the use of Cervarix® during pregnancy.
• Take doctor’s advice  about breast-feeding before receiving

Side Effects

• Very common (side effects which may occur in more than 1 per 10 doses of vaccine):
  • pain or discomfort at the injection site
  • redness or swelling at the injection site
  • headache
  • aching muscles, muscle tenderness or weakness (not caused by exercise)
  • tiredness
• Common (side effects which may occur in less than 1 per 10 but more than 1 per 100 doses of vaccine):
  • gastrointestinal symptoms including nausea, vomiting, diarrhoea and abdominal pain
  • itching, red skin rash, hives (urticaria)
  • joint pain
  • fever (≥38°C)
• Uncommon (side effects which may occur in less than 1 per 100 but more than 1 per 1,000 doses of vaccine):
  • upper respiratory tract infection (infection of the nose, throat or trachea)
  • dizziness
  • other injection site reactions such as hard lump, tingling or numbness.